Yes; Model F and Model M keys can be used on any row of the keyboard, so your keyboard can be rearranged for Dvorak and Colemak for example.  I recommend ordering the extra Dvorak/Colemak homing keys with bump through this store item.  You’d want to order the 2 keys with bump, plus the two “no bump” F and J keys (F and J keys have bumps in the default key sets).

https://www.modelfkeyboards.com/product/new-custom-legend-keycaps/