Well, Cmd and Opt are reversed by default. But it’s super easy to open the Mac’s Keyboard Preferences (behind the Modifier Keys button) and swap them back. It only affects this keyboard — it won’t confuse any other keyboards you have connected.

Regarding Mac compatibility – these are fully Mac compatible as is, but you can order 6 mac keys to have the text on the keys match Mac legends:  https://www.modelfkeyboards.com/product/command-option-keys/

The 6 mac keys are in the same positions on the bottom row of keys as an official Mac keyboard, so re-learning those 6 mac key positions would not be needed if you start using a new Model F keyboard.